2025 newsletter
Happy holidays from the Molecular Oncology Almanac team! Thank you all for the support throughout the year. This was a huge year for development. Here, we'll share a recap of what we have done and where we are going.
2025¶
Posts are organized into categories for ease of navigation:
- Algorithm - developments to the interpretation algorithm implemented in Python.
- Announcement - general news related to the Molecular Oncology Almanac.
- Annual newsletters - annual newsletters that recap updates.
- Database - changes and additions to the underlying knowledge base.
- Release - aggregated release notes from GitHub releases (serving as the project changelog).
Database release
This release contains updates to the current and draft versions of the database with FDA precision oncology approvals from October, November, and December 2025.
Algorithm release 0.8.5
This release utilizes the v.2025-02-07 version of the MOAlmanac database. Cancer Gene Census is also no longer required to run moalmanac. The interpreter version was increased to 0.8.5.
Algorithm release 0.8.4
This release utilizes the v.2025-02-07 version of the MOAlmanac database. Both COSMIC and ExAC are now no longer required to run moalmanac. The interpreter version was increased to 0.8.4.
Follow us on LinkedIn!
You can now follow us on LinkedIn! We'll be sharing our updates on there, in addition to this website and Bluesky.
Database release
This release contains updates to the current and draft versions of the database with FDA and EMA precision oncology approvals from September 2025.
Algorithm release 0.8.3
This release utilizes the v.2025-02-07 version of the MOAlmanac database. It includes a fix to a bug that prevented HTML report generation. Specifically, in rare circumstances, the columns sensitive_score_bin_map, resistance_score_bin_map, and prognostic_score_bin_map were not added to the data object for actionable variants, which are used to sort report tables.
Database release
This release contains updates to the current and draft versions of the database with FDA oncology approvals from June, July, and August 2025. The change log local to this repository has been removed and pointers now direct to news.moalmanac.org. Release notes will also continue to be available through this repository's Releases.
Deprecation notice for Cloud Portal
The Molecular Oncology Almanac cloud portal (portal.moalmanac.org) is currently suspended, and perhaps deprecated, due to Google Cloud's deprecation of the Life Sciences API. It may be revisited at a future date. The algorithm continues to be available through GitHub and Docker Hub.
Launching news.moalmanac.org
Welcome to news.moalmanac.org! Here, we will aggregate software releases from GitHub and share project updates. Thank you for your continued support!