List biomarker criteria¶

{
  "meta": {
    "data_length": 1,
    "message": "Biomarker criteria retrieved successfully",
    "request_url": "https://api.moalmanac.org/biomarker_criteria",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.012345,
    "timestamp_received": "2026-10-16T14:03:12.123456Z",
    "timestamp_returned": "2026-10-16T14:03:12.135801Z",
    "trace_id": "3fa85f64-5717-4562-b3fc-2c963f66afa6"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://moalmanac.org",
    "last_updated": "2026-10-08"
  },
  "data": [
    {
      "id": "bmkr.criterion:16",
      "present": true,
      "subject": {
        "id": "bmkr:16",
        "type": "CategoricalVariant",
        "name": "BRAF p.V600E",
        "constraints": [
          {
            "type": "DefiningAlleleConstraint",
            "allele": {
              "id": "ga4gh:VA.j4XnsLZcdzDIYa5pvvXM7t1wn9OITr0L",
              "type": "Allele",
              "name": "NP_004324.2:p.Val600Glu",
              "aliases": [
                "NP_004324.2:p.V600E",
                "BRAF p.V600E"
              ],
              "description": "VRS variation of NP_004324.2:p.Val600Glu",
              "digest": "j4XnsLZcdzDIYa5pvvXM7t1wn9OITr0L",
              "expressions": [
                {
                  "syntax": "hgvs.p",
                  "value": "NP_004324.2:p.Val600Glu",
                  "extensions": [
                    {
                      "name": "hgvs.p_short",
                      "value": "p.V600E"
                    }
                  ]
                }
              ],
              "location": {
                "id": "ga4gh:SL.t-3DrWALhgLdXHsupI-e-M00aL3HgK3y",
                "type": "SequenceLocation",
                "name": null,
                "aliases": [],
                "description": "Amino acid position 600 of the Refseq protein NP_004324.2, which is the protein product of the MANE Select coding transcript for BRAF (refseq:NM_004333.6).",
                "digest": "t-3DrWALhgLdXHsupI-e-M00aL3HgK3y",
                "sequenceReference": {
                  "id": "ga4gh:SQ.cQvw4UsHHRRlogxbWCB8W-mKD4AraM9y",
                  "type": "SequenceReference",
                  "name": "NP_004324.2",
                  "aliases": [
                    "ensembl:ENSP00000288602.6",
                    "ga4gh:SQ.cQvw4UsHHRRlogxbWCB8W-mKD4AraM9y",
                    "refseq:NP_004324.2"
                  ],
                  "description": "The protein product of the MANE Select coding transcript for BRAF (refseq:NM_004333.6), corresponding to the Refseq protein accession NP_004324.2.",
                  "moleculeType": "protein",
                  "refgetAccession": "SQ.cQvw4UsHHRRlogxbWCB8W-mKD4AraM9y",
                  "residueAlphabet": "aa"
                },
                "start": 599,
                "end": 600,
                "sequence": "V"
              },
              "state": {
                "type": "LiteralSequenceExpression",
                "sequence": "E"
              }
            },
            "relations": []
          },
          {
            "type": "FeatureContextConstraint",
            "featureContext": {
              "id": "gene:hgnc:1097",
              "conceptType": "Gene",
              "name": "BRAF",
              "primaryCoding": {
                "id": "coding:hgnc:1097",
                "code": "HGNC:1097",
                "system": "https://genenames.org",
                "iris": [
                  "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1097"
                ]
              },
              "mappings": [
                {
                  "relation": "exactMatch",
                  "coding": {
                    "id": "coding:ensembl:ensg00000157764",
                    "code": "ENSG00000157764",
                    "system": "https://www.ensembl.org",
                    "iris": [
                      "https://www.ensembl.org/id/ENSG00000157764"
                    ]
                  }
                },
                {
                  "relation": "exactMatch",
                  "coding": {
                    "id": "coding:ncbi:673",
                    "code": "673",
                    "system": "https://www.ncbi.nlm.nih.gov/gene",
                    "iris": [
                      "https://www.ncbi.nlm.nih.gov/gene/673"
                    ]
                  }
                },
                {
                  "relation": "relatedMatch",
                  "coding": {
                    "id": "coding:refseq:NM_004333.6",
                    "code": "NM_004333.6",
                    "system": "https://www.ncbi.nlm.nih.gov/nuccore",
                    "iris": [
                      "https://www.ncbi.nlm.nih.gov/nuccore/NM_004333.6"
                    ]
                  }
                }
              ]
            }
          }
        ],
        "extensions": [
          {
            "name": "biomarker_type",
            "value": "Somatic variant"
          },
          {
            "name": "chromosome",
            "value": "7"
          },
          {
            "name": "start_position",
            "value": 140453136
          },
          {
            "name": "end_position",
            "value": 140453136
          },
          {
            "name": "reference_allele",
            "value": "A"
          },
          {
            "name": "alternate_allele",
            "value": "T"
          },
          {
            "name": "cdna_change",
            "value": "c.1799T>A"
          },
          {
            "name": "protein_change",
            "value": "p.V600E"
          },
          {
            "name": "variant_annotation",
            "value": "Missense"
          },
          {
            "name": "exon",
            "value": 15
          },
          {
            "name": "rsid",
            "value": "rs113488022"
          },
          {
            "name": "hgvsg",
            "value": "7:g.140453136A>T"
          },
          {
            "name": "hgvsc",
            "value": "ENST00000288602.6:c.1799T>A"
          }
        ]
      }
    }
  ]
}