Proposition¶

Dereferenced schema · Source · Referenced version

A VariantTherapeuticResponseProposition. Because Cat-VRS does not yet support sets of categorical variants, subjectVariant is a placeholder and the biomarker criteria are held in the biomarkers extension.

Fields¶

Field	Type	Required
`id`	string matching `^prop:vtxr:\d+$`	yes
`type`	always `VariantTherapeuticResponseProposition`	yes
`predicate`	one of `predictsSensitivityTo`, `predictsResistanceTo`	yes
`subjectVariant`	object	yes
`subjectVariant.type`	always `CategoricalVariant`	yes
`subjectVariant.description`	string	yes
`conditionQualifier`	Disease	yes
`objectTherapeutic`	Therapy or TherapyGroup	yes
`extensions`	array of extensions (see Extensions)	yes

Extensions¶

Each extension is an object with a name, a value, and an optional description (see Extension).

Name	Value	Required
`biomarkers`	array of BiomarkerCriterion (at least 1 item)	yes

JSON Schema¶

Full JSON Schema

{
  "$schema": "https://json-schema.org/draft/2020-12/schema",
  "$id": "https://moalmanac.org/schemas/dereferenced/propositions.schema.json",
  "title": "Proposition",
  "description": "A VariantTherapeuticResponseProposition. Because Cat-VRS does not yet support sets of categorical variants, `subjectVariant` is a placeholder and the biomarker criteria are held in the `biomarkers` extension.",
  "type": "object",
  "properties": {
    "id": {
      "type": "string",
      "pattern": "^prop:vtxr:\\d+$"
    },
    "type": {
      "const": "VariantTherapeuticResponseProposition"
    },
    "predicate": {
      "enum": [
        "predictsSensitivityTo",
        "predictsResistanceTo"
      ]
    },
    "subjectVariant": {
      "type": "object",
      "properties": {
        "type": {
          "const": "CategoricalVariant"
        },
        "description": {
          "type": "string"
        }
      },
      "required": [
        "type",
        "description"
      ],
      "additionalProperties": false
    },
    "conditionQualifier": {
      "$ref": "diseases.schema.json"
    },
    "objectTherapeutic": {
      "oneOf": [
        {
          "$ref": "therapies.schema.json"
        },
        {
          "$ref": "therapy_groups.schema.json"
        }
      ]
    },
    "extensions": {
      "type": "array",
      "items": {
        "anyOf": [
          {
            "$ref": "extension.schema.json",
            "properties": {
              "name": {
                "const": "biomarkers"
              },
              "value": {
                "type": "array",
                "items": {
                  "$ref": "biomarker_criteria.schema.json"
                },
                "minItems": 1
              }
            }
          }
        ]
      },
      "allOf": [
        {
          "contains": {
            "$ref": "extension.schema.json",
            "properties": {
              "name": {
                "const": "biomarkers"
              },
              "value": {
                "type": "array",
                "items": {
                  "$ref": "biomarker_criteria.schema.json"
                },
                "minItems": 1
              }
            }
          }
        }
      ]
    }
  },
  "required": [
    "id",
    "type",
    "predicate",
    "subjectVariant",
    "conditionQualifier",
    "objectTherapeutic",
    "extensions"
  ],
  "additionalProperties": false
}