Molecular Oncology Almanac¶
The Molecular Oncology Almanac (MOAlmanac) is a paired knowledge base and clinical interpretation algorithm for precision oncology. It associates molecular alterations with therapeutic sensitivity, therapeutic resistance and disease prognosis, both for individual events such as somatic variants, copy number alterations, fusions and germline variants, and for global features of a tumor such as tumor mutational burden, microsatellite instability, mutational signatures and whole-genome doubling.
This site documents each part of the project:
| Database | The expert-curated knowledge base, how its records are structured, and a reference page for every schema. |
| API | The public API at api.moalmanac.org, with a reference page for every endpoint. |
| Algorithm | The clinical interpretation algorithm for individual patient samples, and a description of its inputs and outputs. |
| Browser | The web browser at moalmanac.org for searching the database. |
To cite MOAlmanac or a specific database release, see Citation. Each project's source code is on GitHub under vanallenlab.
For research use only
Diagnostic and clinical use is prohibited. See the disclaimer in each repository's README for the full terms.