Proposition¶

Referenced schema · Source · Dereferenced version

A VariantTherapeuticResponseProposition: biomarker(s) predict a therapeutic response in a disease. Exactly one of therapy_id or therapy_group_id is set.

Fields¶

Field	Type	Required	Description
`id`	string matching `^prop:vtxr:\d+$`	yes
`type`	always `VariantTherapeuticResponseProposition`	yes
`predicate`	one of `predictsSensitivityTo`, `predictsResistanceTo`	yes
`biomarker_criteria`	array of string matching `^bmkr.criterion:\d+$` (at least 1 item)	yes
`conditionQualifier_id`	string matching `^dis:(oncotree\|ncit):.+$`	yes	Foreign key to `diseases.id`.
`therapy_id`	string or null matching `^tx:ncit:C\d+$`	yes	Foreign key to `therapies.id`.
`therapy_group_id`	string or null matching `^txgrp:\d+$`	yes	Foreign key to `therapy_groups.id`.

Additional rules¶

These rules also apply to every record:

Exactly one of: therapy_id is string and therapy_group_id is null; or therapy_id is null and therapy_group_id is string.

JSON Schema¶

Full JSON Schema

{
  "$schema": "https://json-schema.org/draft/2020-12/schema",
  "$id": "https://moalmanac.org/schemas/referenced/propositions.schema.json",
  "title": "Proposition",
  "description": "A VariantTherapeuticResponseProposition: biomarker(s) predict a therapeutic response in a disease. Exactly one of `therapy_id` or `therapy_group_id` is set.",
  "type": "object",
  "properties": {
    "id": {
      "type": "string",
      "pattern": "^prop:vtxr:\\d+$"
    },
    "type": {
      "const": "VariantTherapeuticResponseProposition"
    },
    "predicate": {
      "enum": [
        "predictsSensitivityTo",
        "predictsResistanceTo"
      ]
    },
    "biomarker_criteria": {
      "type": "array",
      "items": {
        "type": "string",
        "pattern": "^bmkr\\.criterion:\\d+$",
        "description": "Foreign key to `biomarker_criteria.id`."
      },
      "minItems": 1
    },
    "conditionQualifier_id": {
      "type": "string",
      "pattern": "^dis:(oncotree|ncit):.+$",
      "description": "Foreign key to `diseases.id`."
    },
    "therapy_id": {
      "type": [
        "string",
        "null"
      ],
      "pattern": "^tx:ncit:C\\d+$",
      "description": "Foreign key to `therapies.id`."
    },
    "therapy_group_id": {
      "type": [
        "string",
        "null"
      ],
      "pattern": "^txgrp:\\d+$",
      "description": "Foreign key to `therapy_groups.id`."
    }
  },
  "required": [
    "id",
    "type",
    "predicate",
    "biomarker_criteria",
    "conditionQualifier_id",
    "therapy_id",
    "therapy_group_id"
  ],
  "additionalProperties": false,
  "oneOf": [
    {
      "properties": {
        "therapy_id": {
          "type": "string"
        },
        "therapy_group_id": {
          "type": "null"
        }
      }
    },
    {
      "properties": {
        "therapy_id": {
          "type": "null"
        },
        "therapy_group_id": {
          "type": "string"
        }
      }
    }
  ]
}